Top 5 Muscle Building Supplements You Need to Be Taking

Brad Dieter
Written By: Brad Dieter
July 12th, 2018
Updated: September 23rd, 2021
Categories: Articles Supplements
89.3K Reads
Top 5 Muscle Building Supplements You Need to Be Taking
The 5 most important supplements for gains? Learn which supplements you need to be taking and review the science that makes taking them evident.

A long time ago, in a gym far, far away, someone made the statement, “Man, you don’t need supplements, just eat a good diet and you get everything you need to be jacked”.

Saying you don’t “need” supplements to get jacked is kind of like saying you don’t “need” to deadlift to get strong.

Sure, you might be able to do it. But if you ignore a tool that can help your training, then you are leaving a lot of gains on the table.

Now, the world of supplements can be a bit of a quagmire. It is hard to know exactly what supplements work, how they work, when to take them, etc.

When it comes to building muscle and getting more out of your training, there are 5 supplements that most people would benefit from.

1. Creatine

Creatine supplementation appears to be the most effective legal nutritional supplement currently available for getting you jacked (i.e. enhancing your training and lean body mass). Long story short, creatine works by improving your body’s capacity to produce ATP during short, intense training.1

Related: The Absolute Beginner's Guide to Bodybuilding Supplements

The research surrounding the ergogenic effect of creatine supplementation is pretty mind-blowing. There are easily over 500 peer-reviewed papers on the topic and approximately 70% of the research has reported an increase in exercise capacity.2,3,4

In both the short term and long-term, creatine supplementation appears to enhance the overall quality of training. This often leads to a 5 to 15% greater gains in strength and performance.

If you are trying to get bigger, faster, and stronger, but you’re not taking creatine, you are missing out on some serious gains.

2. Beta-Alanine

Muscle fatigue kills your training.

Remember the last time you were doing weighted dips and you hit the wall and just couldn’t hammer out another rep even if your life depended on it? Beta-Alanine may help you get that extra rep in as it has been shown to reduce muscular fatigue and increase work capacity.

Beta-Alanine Maxing out Dips

Several studies on beta-alanine have that supplementation can increase your work capacity by a few reps when training in moderate rep ranges (8-15).5,6,7 That means more dips for you!

As a result of being able train harder and longer, beta-alanine is effective for muscle hypertrophy, greater fat loss, and improved recovery between sets. Just think about it, if you can train harder and longer you accumulate more volume. More volume = more muscle. Training harder and longer also creates a larger calorie deficit, leading to greater fat loss.

There is also evidence that beta alanine can augment fat loss. However, the most likely reason for this is not due to beta-alanine directly, but the fact that it increases work capacity.8

Beta alanine is also often marketed as a pre-workout ingredient. It is likely marketed that way because the feeling that beta alanine can give you in high doses (the itchy face) makes it seem efficacious.  Don’t let the marketing itchy face and “I’m flying feeling” hype cloud your science. It isn’t really a pre-workout.

Beta-alanine works through bioaccumulation in the muscles. Like creatine, it really doesn’t and probably shouldn’t be taken right before training.  In fact, some evidence indicates that taking it with a meal is best9.

Related: Essential Supplementation - Beta-Alanine: Help or Hype?

Our first two supplements, beta-alanine and creatine, are often stacked together and have been shown to be an excellent combination for individuals looking to increase performance in their anaerobic training. They both work through different mechanisms to increase work capacity, so you might think about taking them together.

The typical dose for beta-alanine is 2-5g/ day. Similar to creatine, it is not dependent upon timing, so it can be consumed at any point during the day, but again taking it with a meal appears to be a bit more effective.

3. Caffeine

Caffeine is currently the best pre-workout supplements for increasing energy, focus, and training capacity. Not only that, caffeine is also capable of increasing aerobic capacity and improving sustained power output.

Several studies have shown that caffeine pre-workout can increase power output 10, 11, 12. However, it appears to not be related to improvements in 1 repetition maximums, but in sustaining power, meaning your 5x3 or 5x5 sets, are likely to improve when taking caffeine.

There have been documented increases in aerobic capacity from caffeine supplementation 13, 14, 15. This could actually be a bad thing. It means you will probably have the physical energy to spend a few more minutes on that torturous stair master.

Scientists think the increased aerobic capacity is due to the increased free fatty acid (FFA) release; however, they aren’t really sure about that. It is likely more of a mental thing than.

5 Supplements You Should take Caffiene

Caffeine is often touted to be a good “fat burner”. Sadly the science on this suggests it’s not really that great at burning extra fat. Most of the fat that is released from fat cells by caffeine dosing is just recylced16. So caffeine probably won’t directly increase fat loss. But like beta-alanine, it may increase your training capacity, making increased fat-loss a byproduct.

Dosing of caffeine is highly variable. Your genetics and habitual use of caffeine play a large role in how much is needed to elicit an effect. The more you consume on a daily basis, the more you will need to consume in order to see any training benefit.

Additionally, there appears to be a “saturation” limit where you only receive an anti-fatigue benefit and no additional effects from higher levels of caffeine intake. Don’t go too high, as too much caffeine actually can kill you (don’t worry about it you 3 pots of coffee a day drinkers, the amount you have to drink is almost physically impossible).

4. Whey Protein

There is an extensive body of research surrounding the efficacy of whey protein supplementation in increasing strength and muscle mass.  There is a substantial amount of evidence suggesting that whey protein helps to increase both strength and muscle mass. 

Interestingly, the things that make up whey protein seem to increase the cell signaling pathways, specifically mTOR, responsible for muscle protein synthesis and muscle hypertrophy. It is believed that this in large part due to high concentrations of leucine present in whey protein.

5 Supplements You Should Take Whey

Whey protein is an excellent source of a wide range of amino acids and additional nutrients that are beneficial to health. Whey protein has been shown to increase lean body mass in conjunction with resistance training, bolster glutathione status, have immunomodulatory effects and improve gut health.

If you have access to a good whey protein and struggle hitting your daily protein needs, you definitely should think about supplementing with whey protein.

5. ZMA

To most of us vitamins aren’t a sexy supplement to take. They either a) remind you of the Flinstone ones you took as a kid or b) some hippy new-age stuff that has nothing to do with getting jacked. Well, it turns out you might want to actually give vitamins and minerals a second chance, especially if you train hard.

Related: ZMA Supplements - Do They Improve Sleep & Test Levels?

ZMA is a supplement that contains the micronutrients Zinc, Magnesium, and Vitamin B.

Zinc is excreted in our sweat, making athletes more susceptible to zinc deficiency.17  Also, unless you are chewing on your zinc plated barbell, it is likely you are aren’t getting much zinc in your diet which makes ZMA a go to supplement for many hard-charging athletes.

Want to keep your testosterone levels from crashing when you are training hard or cutting? Well it turns out that supplementing with zinc during periods of high-training volumes and/or caloric deficits can prevent reductions in testosterone in men18,19.

5 Supplements you Should Take ZMA

Not only does zinc affect testosterone, it also can affect the other important “T” hormone, your thyroid. Supplementing with zinc in athletes has been shown to prevent loses in both T4 and the more bioactive T318,20. Why is this important? Well, the thyroid hormone can kind of be considered the gas pedal to your metabolism. Having robust thyroid function is critical to maximizing your training.

While magnesium has a lot of benefits, the most well known in popular press is that it can help some people with sleep issues.  Taking magnesium was able to improve sleep quality and reduce sleeping cortisol levels in people who had less than desirable sleep21. In another study, taking magnesium improved sleep quality in people who were magnesium deficient22.

Bonus: CinDura (new ingredient)

CinDura is another supplement worth keeping an eye on as early studies show it to be effective in boosting strength and building lean muscle mass.

CinDura is a combination of Garcinia Mangostana fruit rind extract and Cinnamum Tamala leaf extract, both with clinically support to show their ability to boost muscular strength and endurance, thus increasing lean mass.

In fact, in a 42 day randomized, double-blind, placebo-controlled study of 38 recreationally trained participants, those taking CinDura significantly increased their strength, muscular endurance, and lean body mass composition when compared to the placebo group.

  1. Energetics of human muscle: Exercise-induced ATP depletion
  2. Effects of creatine supplementation on performance and training adaptations.
  3. Effect of creatine supplementation on body composition and performance: a meta-analysis.
  4. Creatine supplementation with specific view to exercise/sports performance: an update
  5. Important role of muscle carnosine in rowing performance.
  6. Short-duration beta-alanine supplementation increases training volume and reduces subjective feelings of fatigue in college football players.
  7. Effects of 28 days of beta-alanine and creatine supplementation on muscle carnosine, body composition and exercise performance in recreationally active females
  8. Effects of β-alanine supplementation on performance and body composition in collegiate wrestlers and football players.
  9. Meal and Beta-Alanine Coingestion Enhances Muscle Carnosine Loading.
  10. Effects of caffeine on prolonged intermittent-sprint ability in team-sport athletes.
  11. Effect of two doses of caffeine on muscular function during isokinetic exercise..
  12. Dose response effects of a caffeine-containing energy drink on muscle performance: a repeated measures design.
  13. The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine.
  14. Effect of ambient temperature on caffeine ergogenicity during endurance exercise.
  15. The effects of different doses of caffeine on endurance cycling time trial performance.
  16. Metabolic effects of caffeine in humans: lipid oxidation or futile cycling
  17. Effects of aerobic exercise and training on the trace minerals chromium, zinc and copper.
  18. Effect of fatiguing bicycle exercise on thyroid hormone and testosterone levels in sedentary males supplemented with oral zinc.
  19. Effect of zinc administration on plasma testosterone, dihydrotestosterone, and sperm count.
  20. The effect of exhaustion exercise on thyroid hormones and testosterone levels of elite athletes receiving oral zinc.
  21. Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans.
  22. Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep.
Posted on: Sun, 10/15/2023 - 15:17

I noticed that my blood test showing high level of creatinine while im taking daily creatine .. and the level go back normal when i stopped ! Dose high creatinine level bad ?

M&S Team Badge
Posted on: Mon, 10/23/2023 - 20:11

Hard to answer that question without numbers, and even if you provided them, I would say stop creatine and speak to your doctor, Albert. Apologies for not being better help.

Posted on: Fri, 04/17/2020 - 04:00

How to use 5 supplement times before after workout time

Posted on: Mon, 02/11/2019 - 12:17

Creatine is not a safe supplement. It has many side effect. I experienced heart problems after taking it. This lead me to do my MA thesis on creatine and I found that it’s not beneficial on performance except MAYBE on exercises lasting 10 seconds, which is such a short amount of time to be worth taking creatine. Depending on the type, creatine draws water into or around your muscles making you seem bigger and stronger (creatine does nothing to the muscle fibers making it useless for gaining muscle. Your body naturally produces creatine and excess creatine causes kidney damage. You also get creatine from meat, so why take a needless supplement. I know most won’t agree with this and if you don’t that’s your problem if you don’t mind risking kidney damage or any other health problems, I’m just trying to help. (BA and MA in physical education, CPT through NASM)

Pratapsinh Pabale
Posted on: Wed, 12/25/2019 - 12:48

Chup chutiye

Ian Benn
Posted on: Mon, 10/18/2021 - 02:30

Wow. I think you need to do more research on your part. Creatine has been around since 1909ish. It is the most researched supplement out there. And IT IS COMPLETELY SAFE if you hydrate properly (which you should be doing anyway) and/or if you don't have kidney problems. I have been cycling it for many years. to speak the truth I was the 2nd person in South Africa to take it as a training supplement. I most certainly WILL recommend it as I have only had good results from it bar once when I cramped , but that was my mistake as I was not hydrated enough and was doing a endurance (cycling the Cape Town Argus race)..PERIOD.!!!

Olivia johns
Posted on: Tue, 08/07/2018 - 07:06

It is well said that among different options to gain muscle, supplements that are formulated using herbal extracts. They help you to unleash hidden power before its too late. It invigorates your workout endurance!