Here is a bold statement that will get your attention...
HPN N(r) is the single biggest supplement innovation in the past 5 years.
If you have any interest in brain health, muscle endurance, metabolism or anti-aging, you will want to read the next few paragraphs.
In an industry ripe with BS, N(r) from High Performance Nutrition is an absolute blue chip; a product built on science and university clinical data.
The first thing you should know about N(r) is that it contains only one ingredient. That ingredient is Niagen. Niagen, scientifically known as nicotinamide riboside, is structurally a member of the B-Vitamin family.
Some of you better versed in science will immediately wonder what makes Niagen different from niacin or plain nicotinamide. The best way to explain this is to ask what makes gold different from your credit card or a bank check when traveling in a third world country with no electricity. Gold will be very easy to use and provides you with a lot of bargaining power. On the other hand your credit card and bank check will be virtually useless.
Our body’s inability to efficiently handle niacin in high dosages is well documented, and expressed by a sensation many of you have experienced...the "Niacin Flush". As far as nicotinamide, we cannot achieve the intended benefits without the nicotinamide riboside being absorbed and used in a cohesive manner. In fact, the differences between Niagen and niacin or nicotinamide are so unique that Niagen has three patents. These patents were granted for its production, usage to treat injured or diseased neurons, and its ability to increase the NAD+ coenzyme.
How N(r) Works in One Sentence
N(r) increases the level of NAD+ in every cell of our bodies.
Niagen has a host of benefits that include brain health, muscle endurance, metabolism and anti-aging. All of these benefits are tied into one simple fact: Niagen increases the level of NAD+ in our cells. Through the increase of this coenzyme, all of Niagen's benefits are made possible.
The neuroprotection enhancement capacity of N(r) makes it a no-brainer for athletes participating in contact sports. But many of you are thinking, "Great, that's awesome; but I don't play any sports, what can this really do for me?" The answer to that question is so profound that the rest of this article is dedicated to explaining why N(r) is perhaps the most important supplement you can possibly take, now and forever.
The Mitochondria - Factory Analogy
This needs to be understood, as it will provide a reference point for much of what is to come.
If you paid attention in middle school biology, you remember that the mitochondria are the "energy factories" of the cell. These factories are responsible for turning glucose, amino acids and fatty acids into ATP, our body’s usable energy source.
What wasn't covered in biology class was the fact that the capacity of mitochondria is mostly determined by their size and cristae content. Cristae are the channels of the mitochondria where most activity occurs. So essentially, they are the "assembly lines" of the mitochondrial "factory."
Bigger mitochondria with more cristae are like larger factories with more assembly lines.
Why is This Such a Big Deal?
Imagine you had a factory that made shoes. This factory would take in laces, soles and leather, and in turn would produce shoes.
Now assume that the factory could produce a maximum of 100 pair of shoes per day based on its size and the number of assembly lines in the factory. What would happen if you demanded that it produce 200 pair of shoes per day? Because 200 pair of shoes is far beyond the capacity of the factory, demanding such an output would put a great deal of stress on the factory. In turn, you would likely see a huge increase in the number of defects and waste.
Now using this logic, let's apply it to the mitochondria. Many researchers speculate that our mitochondria have become dysfunctional over the last couple thousand years of civilization, and that they are currently unable to meet the energy production needs we place upon them.
So, as with the shoe factory scenario, this situation creates an immense amount of mitochondrial stress. This increases the amount of free radical waste that the mitochondria puts out when trying to produce the ATP we need to fuel our bodies. As you can imagine, this will be particularly bad in both very active persons who demand a lot of ATP to fuel their activities; and in populations that have poor dietary habits including highly processed foods that may be harder for the body to metabolize.
The Free Radical Problem
So we are faced with a situation where the mitochondria are putting out a lot of free radicals into the cells. The problem with free radicals is that they speed up aging, and are thought to be a potential cause of cancer and other diseases.
The approach in the dietary supplement industry has been to take antioxidants in an attempt to neutralize these free radicals and prevent them from doing the harm they are known to do. The issue with this approach is that we are forever behind and unable to effectively manage the free radicals.
The analogy is similar to oil tankers spilling oil into the ocean. The oil in the ocean is like free radical in our bodies. When oil is spilled in the ocean, the immediate goal is to remove it. The machines and procedures that are used in an attempt to clean up the spill can be compared to antioxidants cleaning up free radicals in our bodies. The machines and the antioxidants can be effective; but certainly the vastly superior solution would be to minimize/prevent the oil spill or free radical production.
With oil companies the solution is simple, DON'T SPILL THE OIL. Our bodies however, have been a much greater challenge. How can we make our mitochondrial factories stronger, more functional, and more efficient to reduce the stress on them and thus minimize free radical output?
Now Lets Revisit WHAT N(r) DOES
N(r) has been proven in university research to:
- INCREASE NAD+ levels to improve mitochondria-nucleus communication
- INCREASE mitochondrial size
- INCREASE mitochondrial cristae content
- INCREASE the number of mitochondria (Mitochondrial Biogenesis)
If you recall, mitochondrial size and cristae content are two dominant factors in determining mitochondrial capacity. The third proven mitochondrial benefit of N(r) was that it actually increased the actual number of mitochondria in the cells.
So as a final recap, in this one supplement we have created a safe and effective means of giving you more mitochondria, each of which are functioning at a higher level than ever before possible.
However, it still gets better. Increasing mitochondrial function does more than just decrease free radical output. Additional benefits include:
- Increased calorie expenditure (metabolism) - This can help create additional fat loss in conjunction with diet and exercise.
- Increased ATP availability/production - ATP is a key component to maximizing energy levels and muscle performance in any activity or sport.
This makes N(r) a must have for anyone who takes their health, performance, or physique seriously.
Canto; The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity; Cell Metabolism (2012) 15:838-847.
Sasaki;Stimulationofnicotinamideadeninedinucleotidebiosyntheticpathwaysdelays axonal degeneration after axotomy; The Journal of Neuroscience (2006) 33:8484-8491.
Gomes: Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging; Cell Journal (2013)