Phenibut Information & FAQs
Phenibut information, FAQ and product listing page. This page contains information and frequently asked questions about phenibut as well as a complete list of products containing phenibut.
Quick jump to the sub-sections on this page:
What is phenibut and what does it do?
Phenibut, also with the spelling of fenibut, is a derivative of GABA, a neurotransmitter that crosses the blood-brain barrier. It was created in Russia and has been used clinically there since around the 1960s for a wide variety of purposes. Phenibut is commonly compared to Valium, with similarities to the drug, as well as some differences. Phenibut has anxiolytic and nootropic properties.
Structurally speaking, GABA and phenibut are similar, as is PEA and baclofen. GABA is the one crucial inhibitory neurotransmitter in your brain. With the combining of the phenyl ring to GABA, it is more easily able to cross the barrier between blood and brain. In addition, it also changes it’s activity profile.
Due to the similar structure of PEA, phenibut may also share some of it’s similarities, as well as differences. When PEA and phenibut are taken together, it provokes some of the effects it brings like the promoting of hyperthermia, anxiety, as well as seizures. This makes some believe that provoking PEA could possibly be the trigger for the anxiolytic traits to take effect with phenibut.
Phenibut is also known to increase dopamine levels, with the structure of PEA believed to play a crucial part in this ability.
What are the benefits of taking phenibut?
There have been extensive animal tests performed on phenibut and its ability to reduce anxiety. These tests have generated positive results, but there is commonly dependence in study conditions. In tests, cats that were classified as being passive or active had their fear response and aggression reduced by phenibut in a confrontational situation.
Phenibut when given to mice increased their social behavior and normal cats that were given phenibut displayed characteristics described as “positive emotional symptoms.” When given to rats, phenibut was able to elevate the levels of glucorticoid levels and decrease a few of the physiological responses endured during times of stress. While the effects are weaker than those a diazepam, phenibut had a tranquilizing effect similar to the substance. In addition, phenibut caused sedation and muscle relaxation – but likewise, these effects were much weakear than those that were caused by diazepam.
In Russia as it is used today, phenibut is commonly used to treat different types of neuroses, which includes insomnia, stuttering, and PTS disorder, or post-traumatic stress disorder. Phenibut in double blind placebo studies has been found to improve physical strength, increase intellectual function and aquity, as well as reduce the fatigue felt in psychotic and neurotic patients.
Who can benefit from taking phenibut?
As phenibut is considered to be connected to a variety of positive health benefits, many adults suffering from a myriad of health conditions should consider taking phenibut. This includes adults that are inflicted with anxiety, insomnia, PTS, and stuttering. In addition, phenibut may also increase physical strength and improve mental acuity and might be taken to assist in those areas.
How much phenibut should I take?
You should always strictly adhere to the supplement of the label that you are taking.
Does phenibut have any side effects?
No signs of toxicity have been reported in clinical studies, and side effects have been few. Some individuals have reported a minor case of drowsiness.
One should be alert about the possibility for drug interactions when using phenibut. In some cases, mixing phenibut with another drug like opiates or GHB will amplify the drugs effects, while on the other hand mixing it with stimulants will diminish their effect.
Products That Contain Phenibut:
The phenibut product list is coming soon!
Sources used:
Eur J Pharmacol. 1993 Mar 16;233(1):169-72. R-(-)-beta-phenyl-GABA is a full agonist at GABAB receptors in brain slices but a partial agonist in the ileum. Ong J, Kerr DI, Doolette DJ, Duke RK, Mewett KN, Allen RD, Johnston GA.
Farmakol Toksikol. 1985 Jul-Aug;48(4):50-4. [Differences and similarity in the interaction of fenibut, baclofen and diazepam with phenylethylamine] [Article in Russian]. Lapin IP.
Pharmacol Toxicol. 1990 Jan;66(1):41-4. Stress-protection action of beta-phenyl(GABA): involvement of central and peripheral type benzodiazepine binding sites. Rago L, Kiivet RA, Adojaan A, Harro J, Allikmets L.
Ross Fiziol Zh Im I M Sechenova. 2001 Sep;87(9):1217-26. [Neurochemical characteristics of the ventromedial hypothalamus and anti-aversive effects of anxiolytic agents in various anxiety models] [Article in Russian]. Talalaenko AN, Pankrat'ev DV, Goncharenko NV.
Farmakol Toksikol. 1991 Nov-Dec;54(6):44-6. [The effect of GABA-ergic agents on oxidative phosphorylation in the brain mitochondria in traumatic edema] [Article in Russian]. Novikov VE, Sharov A.
Med Tr Prom Ekol. 1997;(5):35-8. [Experimental bases of the use of pharmacologic agents aimed at higher heat resistance of humans as means of individual protection] [Article in Russian]. Makarov VI, Tiurenkov IN, Klauchek SV, Nalivaiko IO, Antipova AIu.
