Yok3d

It's the ultimate sign of respect...

While terms like huge, diesel & ripped are thrown around on a daily basis, Yoked is reserved for the elite...

Only the baddest bad ass in the place can legitimately be called Yoked...

Slapped Upside Your Head

Call someone Yoked who doesn't deserve it and expect to get slapped silly...

When you're Yoked, you just look different. Muscles are thick and dense - like slabs of beef...

...Cuts run deep and look like they've been etched by a jackhammer, while veins resemble a Rand McNally map...

When You're Truly Yoked, You're The Total Package...

And...Quite frankly...dudes want to be you & chicks want to be with you ...

They Just Kept Saying "I Feel Yoked!"

Every now and then a product comes across my desk that I immediately KNOW is different...

And not just a little different, but REALLY different-causing our testers to go crazy......And as soon as our guys were saying things like "Man, the pump from these tiny pills is off the charts.* My muscles are full, pumped and hard as a rock.* I feel different . I feel Yoked!" I knew we were on to something...

The Little-Known "Reverse" Nitric Oxide Pathway

Up until this point, most Nitric Oxide (N.O.) products have relied on the Classic, Old-School Nitric Oxide Pathway, otherwise known as the "L-Arginine-N.O.-Synthase pathway"...

This is the pathway utilized by compounds such as L-Arginine and is a decent method to elevate N.O. and give you better gains in the gym and greater pumps...*

Sure, it's nothing ground-breaking, but it's very popular with lifters the world over and has proven to be a popular pathway among users...

Nitrate-Nitrite What?

Now, on to the really exciting stuff...

What if I told you there was another N.O. pathway?

...And...What if I told you this little-referenced pathway blows away the classical N.O. pathway in its ability to enhance N.O. within the body, especially for weight training?

Would you be excited?

Of course you would...

Well, it does exist and we call this little-known pathway the "REVERSE" Nitric Oxide pathway, scientifically known as the Nitrate-Nitrite-Nitric Oxide Pathway.

If You Weight Train-The "Reverse" Nitric Oxide Pathway Is Like Striking Oil In Your Backyard While Planting A Tree...

It can generate nitric oxide via several routes that are enzymatic and non-enzymatic, making this pathway, in some respects, a more reliable and better overall way to increase N.O. (1-4).*

Furthermore, this pathway becomes much more important and is favored over the classical pathway in conditions where oxygen levels are much lower and to some extent acidification occurs in a given tissue (i.e. weight training), allowing for vasodilation to occur and oxygen to be transported in these conditions.*

We can utilize both pathways to obtain very high N.O. levels to achieve an optimal level of vasodilation.*

The graph above demonstrates two Nitric Oxide Pathways; The classic L-Arginine & the amazing "Reverse" Nitrate-Nitrite-N.O. Pathway

Not Just A Pretty Pump

This increased N.O. and vasodilation may at least be partially responsible for a potential improvement of exercise efficiency by reducing the amount of oxygen and energy needed in the form of ATP and phosphocreatine during exercise and muscle contraction...*

In short, it may allow you to be more resistant to fatigue and squeeze out a little more during your workouts, whether that's just a few more reps when weightlifting or allowing you to stay in the game a little longer.*

It's also worth noting that this notion of nitrate increasing vasodilation and improving exercise performance isn't just hypothetical. Several studies have surfaced recently which have demonstrated that nitrate can and does accomplish just that (5-12).

So, with this data in hand, we set out to develop Yok3d utilizing both of the above pathways along with other compounds that round out this incredible breakthrough...

Performance Pump

With USPlabs Yok3d, long gone are the days of a hollow, bloated, shallow pump that doesn't do didly squat for your true physique...

Not only can improved performance be achieved, but by causing the levels of vasodilation that it's capable of, one may also increase amino acid and glucose transport into skeletal muscle, potentially enhancing muscle growth and recovery (33-36).*

It should go without saying that this can also lead to much greater pumps and the feeling of fuller muscles...*

And it's a much different type of pump-muscles are dense & hard, not puffy & bloated.*

Huge Horse Pills No More

Let's face it, no one likes taking huge, chalky pills that can make you gag...That's for chumps...

That's why we've made Yok3d so efficient that the pills are tiny in comparison to traditional "pump pills"...

8, 10, 12 Pills or More Everyday?

Yeah, no thanks homie...

Yok3d is so efficient it's taken on workout days ONLY!

Pop a few pills about 90-120 minutes before your workout (more on why this timing is critical to "unlocking" Yok3d's efficiency) and you're good to go...

On the left is a single dose of Yok3d, taken on workout days only...on the right is a daily dose of a popular "pump" product...which would you rather take?

Crazy Value!

You shouldn't have to take out a mortgage to get a pump. Its borderline obnoxious how much some of these pump pills cost...

Just like USPlabs is known for, we've built in crazy value to Yok3d so each bottle lasts at least a month...

...with many users getting an additional week or two more out of it!

You're About To Get Bombarded With Nitrates

Mark my words, nitrate-based products are going to be the "next big thing" shoved down your throat...

They will be in everything ...pre-workouts, intra-workouts, post-workouts, pre-bed, heck even proteins...

Companies will haphazardly combine nitrates in the same product and in recommended stacks...

...But the fact of the matter is, this is flat-out completely irrational and uneducated application...

Timing & dose is crucial ...

You can't just throw nitrates in everything and hope for the best as too much nitrate can actually have negative side effects along with not being as effective!

It's ALL About The Correct Dose For YOU...

In addition to timing of nitrates being a critical factor, individual dose is also vital to maximizing any nitrate-based product...

This is why we recommend that you start with 3 capsules (2 for those under 140 pounds) of Yok3d on workout days only and go from there. We provide a dosing chart on each label for a guide, but it's just a guide, you have to find what works best for you...

Take too much or too often and you won't like the results. Gone are the days of having to take a Nitric Oxide enhancing pill multiple times per day or even every day for that matter...

Don't Waste Your Nitrates

Don't cheat yourself and waste your money by following incorrect dosing guidelines...

Instead of making random guess as to when you should consume a serving of Yok3d, we have used published kinetic data on nitrates to determine our dosing for Yok3d.

You see, if you consume a serving of nitrates and then begin working out only 15-45 minutes later, you're wasting a great deal of the product's efficacy.

Studies have surmised that nitrate levels begin to increase as early as 10 minutes after ingestion and they generally peak anywhere from 30 minutes to 1.5 hours and in some cases, the peak may take even longer to occur (37-41).*

Yet, it would be a MAJOR mistake to time the dose based upon nitrate concentrations alone because the activity (i.e., increased Nitric Oxide) that we're after is actually directly derived from nitrite, the reduced product of nitrate.

In effect, you want nitrite levels to be highest when you're working out as nitrite is first in line for conversion to N.O.

Looking at the studies which have evaluated nitrite levels after nitrate administration, we find that N.O. doesn't begin to increase substantially over that of baseline values until 1-2 hours post administration where levels reach a peak between 2-3 hours after administration...

...Simply put...

You've Got To Allow Your Body Time To "Unlock" This Incredible, Highly Complex Metabolic Cascade So It Can Work To Your Advantage...

It is no coincidence that indicators of vasodilation and certain performance markers aren't significantly affected until at least 60-90 minutes post administration and don't reach a peak until the 2 hour or greater mark (37, 42).

BOTTOM LINE: Don't take nitrates at the same time as your pre-workout, take them before...

General References:

• Weitzberg E, Hezel M, Lundberg JO. Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care. Anesthesiology. 2010 Dec;113(6):1460-1475
• Lundberg JO & Weitzberg E. NO generation from inorganic nitrate and nitrite: Role in physiology, nutrition and therapeutics. Arch Pharm Res. 2009 Aug;32(8):1119-1126
• Lundberg JO, Weitzberg E, Gladwin MT. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov. 2008 Feb;7(2):156-167
• NO generation from nitrite and its role in vascular control. Arterioscler Thromb Vasc Biol. 2005 May;25(5):915-922
• Larsen FJ, et al. Effects of dietary nitrate on oxygen cost during exercise. Acta Physiol (Oxf). 2007 Sep;191(1):59-66
• Bailey SJ, et al. Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. J Appl Physiol. 2010 Jul;109(1):135-148
• Larsen FJ, et al. Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise. Free Radic Biol Med. 2010 Jan 15;48(2):342-347
• Bailey SJ, et al. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Apply Physiol. 2009 Oct;107(4):1144-1155
• Webb AJ, et al. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension. 2008 Mar;51(3):784-790
• Vanhatalo A, et al. Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol. 2010 Oct;299(4):R1121-R1131
• Lansley KE, et al. Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study. J Apply Physiol. 2010. Published Ahead of Print. Dejam A, et al. Effects of dietary nitrate on blood pressure. N Engl J Med. 2007 Apr 12;356(15):1590
• Ralt D. Does NO metabolism play a role in the effects of vegetables in health? Nitric oxide formation via the reduction of nitrites and nitrates. Med Hypotheses. 2009 Nov;73(5):794-796
• Lundberg JO, et al. Roles of dietary inorganic nitrate in cardiovascular health and disease. Cardiovasc Res. 2010. Published Ahead of Print. Lundberg JO. Cardiovascular prevention by dietary nitrate and nitrite. Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1221-1223
• Lundberg JO, et al. Cardioprotective effects of vegetables: is nitrate the answer? Nitric Oxide. 2006 Dec;15(4):359-362
• Hord NG, Tang Y, Bryan NS. Food sources of nitrate and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr. 2009 Jul;90(1):1-10
• Kapil V, Webb AJ, Ahluwalia A. Inorganic nitrate and the cardiovascular system. Heart. 2010 Nov;96(21):1703-1709 Tharakan B, Dhanasekaran M, Manyam BV. Antioxidant and DNA protecting properties of anti-fatigue herb Trichopus zeylanicus. Phytother Re. 2005 Aug;19(8):669-673
• Singh B, Gupta DK, Chandan BK. Adaptogenic activity of a glycol-peptido-lipid fraction from the alcoholic extract of Trichopus zeylanicus Gaertn. Phytomedicine. 2001 Jul;8(4):283-291
• Tharakan B, et al. Trichopus zeylanicus combats fatigue without amphetamine-mimetic activity. Phytother Res. 2006 Mar;20(3):165-168
• Singh B, et al. Adaptogenic activity of glycol-peptido-lipid fraction from the alcoholic extract of Trichopus zeylanicus Gaerten (part II). Phytomedicine. 2005 Jun;12(6-7):468-481
• Evans DA, et al. Effect of Trichopus zeylanicus leaf extract on the energy metabolism in mice during exercise and at rest. Indian J Pharmacol. 2002;34:32-37
• Subramoniam A, et al. Aphrodisiac property of Trichopus zeylanicus extract in male mice. J Ethnopharmacol. 1997 Jun;57(1):21-27
• Heller R, et al. L-ascorbic acid potentiates nitric oxide synthesis in endothelial cells. J Biol Chem. 1999 Mar 19;274(12):8254-8260
• Muller-Delp JM. Ascorbic acid and tetrahydrobiopterin: looking beyond nitric oxide bioavailability. Cardiovasc Res. 2009 Nov 1;84(2):178-179
• Tomasian D, Keaney JF, Vita JA. Antioxidants and the bioactivity of endothelium-derived nitric oxide. Cardiovasc Res. 2000 Aug 18;47(3):426-435
• Carlsson S, et al. Effects of pH, nitrite, and ascorbic acid on nonenzymatic nitric oxide generation and bacterial growth in urine. Nitric Oxide. 2001 Dec;5(6):580-586
• Modin A, et al. Nitrite-derived nitric oxide: a possible mediator of 'acidic-metabolic' vasodilation. Acta Physiol Scand. 2001 Jan;171(1):9-16
• Lafay S, et al. Grape extract improves antioxidant status and physical performance in elite male athletes. J Sports Sci and Med. 2009 Sep 1;8:468-480
• Rocha BS, et al. Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation. Toxicology. 2009 Nov 9;265(1-2):41-48
• Gago B, et al. Red wine-dependent reduction of nitrite to nitric oxide in the stomach. Free Radic Biol Med. 2007 Nov 1;43(9):1233-1242
• Biolo G, et al. An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am J Physiol. 1997 Jul;273(1 Pt 1):E122-129
• Baron AD, Clark MG. Role of blood flow in the regulation of muscle glucose uptake. Annu Rev Nutr. 1997;17:487-499
• Low SY, Rennie MJ, Taylor PM. Modulation of glycogen synthesis in rat skeletal muscle by changes in cell volume. J Physiol. 1996 Sep 1;495 (Pt 2):299-303
• Haussinger D, et al. Cellular hydration state: an important determinant of protein catabolism in health and disease. Lancet. 1993 May 22;341(8856):1330-1332
• Webb AJ, et al. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension. 2008 Mar;51(3):784-790
• van Velzen AG, et al. The oral bioavailability of nitrate from nitrate-rich vegetables in humans. Toxicol Lett. 2008 Oct 1;181(3):177-181
• Cortas NK & Wakid NW. Pharmacokinetic aspects of inorganic nitrate ingestion in man. Pharmacol Toxicol. 1991 Mar;68(3):192-195
• Lundberg JO & Govoni M. Inorganic nitrate is a possible source for systemic generation of nitric oxide. Free Radic Biol Med. 2004 Aug 1;37(3):395-400
• Govoni M, et al. The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash. Nitric Oxide. 2008 Dec;19(4):333-337
• Vanhatalo A, et al. Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol. 2010 Oct;299(4):R1121-R1131