What's the supplement that burns fat faster than an ice cube melts in the Sahara? Meltdown® mi amigo! In a study unveiled at the June 2008 International Society of Sports Nutrition Conference in the beautiful Red Rock Hotel, researchers discovered that this fat eliminating supplement jacked up metabolic rates so much so that it left scientists scratching their heads as to how it compared to other popular thermogenics. That's a finding of groundbreaking proportions.*
What does this mean? Think about it Sherlock. If you take Meltdown before training, your metabolic rate will go through the roof faster than Anderson Silva can put you in an arm bar! You'll get rid of fat faster and you'll get that lean physique you've always worked for and deserve!*
The Research & Development group at VPX has more earth-shattering science coming down the pike this year. So buckle your chinstraps and get ready for the ride of your thermogenic life! Hasta la vista!
Meltdown Science: Combines the synergistic fat burning power of beta andrenergic agonists (MethylSynephrine) and alpha andrenergic antagonists (Yohimbine HCl, alpha-Yohimbine and 11-Hydroxy Yohimbine). In simpler terms it activates fat burning mechanisms in your body while simultaneously blocking the internal biochemistry that prevents you from burning fat by guarding one of the body’s key fat burning hormones called Norepinephrine (NE). When fat burning is both promoted and protected at the same time we call this effect "synergistic". So, instead of 9 (activation factor) + 8 (protection factor) equaling 17 on the fat burning scale, this synergistic combination has a geometric effect of 72!*
The powerful fat loss agent, 11-Hydroxy Yohimbine is of great interest here because regular Yohimbine yields a roughly 32% increase in the fat burning hormone, NE. Compare this to 11-Hydroxy Yohimbine that yields an even more impressive research proven 56% increase in the potent fat burning hormone, NE. We are only now just studying how the combination of the other Yohimbine compounds in Meltdown work in concert to increase NE even further. With the combined effect of alpha-Yohimbine and 11-hydroxy Yohimbine contained in Meltdown blocking both alpha-1 and alpha-2 receptors, my hypothesis is that we are looking at a 81%+ increase in NE!*
This is only the tip of a large scientific iceberg Meltdown!
Yohimbine HCl, 11-Hydroxy & Alpha Yohimbine 11-Hydroxy Yohimbine 11-hyrdoxy Yohimbine is the active metabolite of Yohimbine. Research indicates that 11-hydroxy Yohimbine has a potent alpha-2 adrenergic receptor affinity that significantly increases lipid metabolism. 11-Hydroxy Yohimbine exhibits a 10 fold increase in the binding ability to alpha-2 adrenergic receptors. The half-life of 11-hydroxy Yohimbine is approximately 8 to 11 hours compared to Yohimbine’s two hour half-life. 11-Hydroxy Yohimbine offers definite advantage over Yohimbine in alpha-2 adrenergic receptors binding affinity and the longer half life in blood. The body converts Yohimbine to 11-hydroxy metabolite in the liver. Consequently, it is Meltdown’s unique Yohimbine Tri-Matrix that works synergistically to increase unmatched norepinephrine- induced fat burning in both potency and duration of action.*
Methyl Synephrine (MS) -- as previously mentioned MS is a beta-3 AA just like real Clenbuterol! The magnificence of a beta-3 Andrenergic Agonist lies in it’s ability to burn fat with out causing anxiety like its chemical cousin, ephedrine which is a beta-2 Andrenergic Agonist.*
The active Methyl PEA isomer, R-beta Methylphenylehtylamine – found botanically in nature and found also in chocolate, is a simpler form called PEA has been called the love compound. Think of Meltdown’s R-beta Methylphenylehtylamine as the love compound in overdrive dramatically enhancing the sexual experience and many other aspects of fat loss and is trademarked by VPX as Craving Control® and Mind Control Matrix™ for its potent ability to shut down appetite and eliminate carbohydrate cravings.*
MTTA is another really impressive research proven compound that causes apoptosis or systematic death to fat cells. Meltdown is also designed to increase mental clarity and mood with minimal jitteriness while burning fat at an unprecedented rate.*
Meltdown® by VPX is the most profound scientific fat loss innovation of the decade. Meltdown has a star studded ingredient profile of newly invented exclusive fat loss compounds designed to burn fat faster and longer by kicking up a thermogenic storm! And that's just the tip of a very large iceberg of fat burning science. Meltdown will radically increase energy levels, take mental acuity and alertness into the stratosphere and induce an intense mood-altering euphoric effect that is going to re-write fat loss biochemistry. Meltdown is also highly pro-sexual. In fact I'll guarantee that you have the best sex you ever experienced shortly after taking Meltdown! However, we are only here today to talk about fat loss.*
Yohimbine is an alpha-2-antagonist which simply means it exerts its fat loss magic by blocking the alpha-2 receptors. Blocking action of the alpha-2 receptors is critical for fat loss because it increases blood flow in adipose tissue and as a result ramps up internal fat metabolism causing previously stored body fat to be released into the blood stream and burned as energy. This process is known as Lipolysis. Yohimbine also works by increasing Norepinephrine (NE) - one of the body's principal lipolytic (fat burning) hormones. The challenge is that when NE is released it stimulates both the alpha and beta receptors. While stimulating the beta receptors causes the desired effect of fat liberation, NE simultaneously also stimulates the alpha-2 receptors which can have the undesired effect of interfering with the process of body fat being burned as energy. Yohimbine is a really cool substance because it exerts a kind of self-protective mechanism by blocking the alpha-2 receptors and guarding one of the body's key fat burning hormones called Norepinephrine. Simply stated, it is almost like Yohimbine has a mind of its own that says I'm going to increase NE to destroy body fat and nothing is going to get in my way.*
Because of the sheer fat burning potency of Yohimbine, we analyzed this chemical very closely and now introduce two new forms (along with Yohimbine HCl) of Yohimbine in Meltdown. Consequently, Meltdown contains three specialized forms of the potent fat loss agent, Yohimbine. It's no secret that when it comes to burning fat, milligram per milligram, Yohimbine is even more effective than ephedra. Along with pure Yohimbine HCl, Meltdown now contains 11-Hydroxy Yohimbine which has unusually long half-life and, therefore, exerts a prolonged research-proven fat burning effect for up to eight hours while increasing norepinephrine levels by up to 56%! This is important because Norepinephrine (NE) is one of the body's principal lipolytic (fat burning) hormones. Further, Meltdown also contains the rare alpha-Yohimbine compound. The scientific marvel is that Yohimbine HCl, 11-Hydroxy Yohimbine and alpha-Yohimbine work synergistically to increases lipolysis. These compounds work particularly well in the stubborn areas of the butt, thighs and abdomen because of the Yohimbine receptor cites concentrated in those areas.*
Interestingly, most of these compound innovations contained in Meltdown didn't even exist and had to be chemically engineered in the lab. For example, 20 milligrams Synephrine is supposed to be a fairly decent fat loss compound similar in action and chemical structure to ephedrine. So we set up a human subject study and tested all the parameters of fat loss using 1) 25 mgs of pure Synephrine then, 2) 50 mgs of pure Synephrine HCl (hydrochloride) and finally, 3) 200 mgs of pure Synephrine HCl. Even when these high amounts of pure Synephrine were stabilized with HCl and bound to a polymer-lipid based delivery system, thermogenisis was not induced. Furthermore, energy, heart rate and oxygen uptake did not increase nor were any other markers of fat loss apparent! We were about to give up on Synephrine until I came up with one last creative effort to get this compound to work. We turned to several molecular modifications of Synephrine to see if this scientific approach would make this compound an effective fat loss agent. I must admit that there was a great deal of apprehension because generally speaking, if an ingredient doesn't work to begin with, it normally doesn't work no matter what you do to the chemical structure. The answer to the Synephrine challenge was to chemically engineer Methyl Synephrine. To our delight Methyl Synephrine didn't make your heart race or give you anxiety like ephedrine but provided almost equal amounts of thermogenisis, energy and feeling of well being. After perfecting Methyl Synephrine, human subjects were excited about its effectiveness and our scientific team was even more excited knowing how well beta andrenergic agonists stack with alpha antagonists in regard to fat loss.*
With Yohimbine HCl, 11-hydroxy Yohimbine, alpha-Yohimbine and Methyl Synephrine VPX could have easily stopped here and delivered the best fat stacked together have a significant synergistic effect to cut fat and that ephedrine and caffeine stacked with Yohimbine had an even greater capacity to destroy fat. Therefore, we theorized that combining caffeine with Methyl Synephrine (the chemical cousin of ephedrine) would exert a similar fat loss effect. More importantly, we theorized that we could even beat the old-school Ephedrine-Caffeine-Yohimbine combination with a more scientifically hip: Caffeine-Methyl Synephrine-Yohimbine HCl, 11-hydroxy Yohimbine, alpha-Yohimbine stack. And, human subjects (including myself) confirmed that our theory was correct! All my staff and I can say is that this combination rocks, period!*
Phenylethylamine (PEA) processes the unique capacity to increase metabolism by stimulating your thyroid gland and inducing thermogenisis to burn fat while eliciting the mild euphoria of eating a 1000 chocolate bars. So imagine if you could take PEA and make it 40 to 60 times more effective? Meltdown may give you the buzz of 40,000 fat and calorie free chocolate bars while melting fat off faster than a blow torch! Therefore, it was now time to add our new breakthrough fat loss compounds called, R-ß-M-PEA (R-ß-Methylphenylethylamine) and n-Methyl-ß-PEA (n-Methyl-ß-Phenylethylamine). We originally began working with ordinary ß-PEA and ß-PEA HCl but found these compounds to have far too many limitations. First, they were metabolized far too quickly and secondly, their ability to cross the blood brain barrier was weak and could, therefore, be astronomically improved up to 40 to 60 times by using the R-ß-M-PEA and n-Methyl-ß-PEA versions! This is mind boggling considering that most consumers and other supplement companies are already satisfied with ordinary PEA. But remember, I'm staking my entire career and reputation on my guarantee that Meltdown® is the most profound scientific fat loss innovation of the decade!*
It is commonly known to skilled biochemists that the kinetics of any version of PEA can be extended when combined with an MAO inhibitor. However, I was highly disappointed with lack of MAO inhibiting capacity of Hordenine and Hordenine HCL. We needed this compound to kick butt for two major reasons. To achieve the desired MOA inhibition effect, we again had to alter the basic chemical structure to create a super type of High Powered Hordenine. Unlike straight Hordenine or Hordenine HCl, this special Hordenine had to be a potent MAO inhibitor to prevent PEA from being metabolized by the monoamine oxidase (MAO) enzyme. Blocking MAO would increase the duration of action of our brilliant R-ß-M-PEA and n-Methyl-ß-PEA inventions and permit easy transport across the blood brain barrier. In medicine this is called increasing the pharmacokinetic value. This would allow R-ß-M-PEA and n-Methyl-ß-PEA – two of the most potent legal designer fat loss compounds - to become even more efficacious.*
Of equal importance, adding the appropriate functional group to the chemical structure would also ramp up Hordenine's intrinsic andrenergic fat burning capacity. So, after attempting to stabilize Synephrine with HCl and failing at hydroxylation to make it more soluble as was accomplished with 11 Hydroxy Yohimbine, we finally arrived at adding a Methyl functional group to Hordenine thus giving birth to "Undisputed King of all MOA Inhibitors called, Methyl Hordenine AKA High Powered Hordenine! - not to mention that Methyl Hordenine and Methyl Synephrine are an outstanding beta adrenergic agonist fat loss stack that works synergistically with the triple Yohimbine alpha 1 and alpha 2 andrenergic antagonists. And, we are all well aware from old days of the Ephedrine (an andrenergic agonist), Caffeine and Yohimbine stack that Caffeine further enhances the effect of andrenergic agonists like Methyl Hordenine/Methyl Synephrine and Yohimbine. And, our Methyl Hordenine innovation produced effects beyond our wildest imagination with real human subjects when combined with R-ß-M-PEA and n-Methyl-ß-PEA and the other above-mentioned compounds in Meltdown. This resulted in a super clean mild "X" buzz with unprecedented mental acuity that lasted for hours and extended thermogenisis, carb Craving Control® and other markers of fat loss.*
Caution: Synephrine DOES NOT WORK! I hate to burst your bubble but Synephrine and Synephrine HCl are as useless as a screen door on a submarine. However, Methyl Synephrine is an off the chain version of Synephrine. This adrenergic amine robustly accelerates fat metabolism and thermogenisis to simultaneously speed up the fat burning process. Unlike its chemical cousin Ephedrine, Methyl Synephrine has mild stimulating properties on the central nervous system which is highly desirable because you get ultimate fat burning properties without the racing heart and anxiety that ephedrine caused. This is because Ephedrine works at the beta 2 receptor which acts on the CNS (central nervous system) and may have side effects in unhealthy individuals while, Methyl Synephrine is one of the adrenergic amines that stimulates the beta-3 receptors. This functions to increase the metabolic rate without affecting heart rate or blood pressure. Synephrine releases epinephrine and norepinephrine primarily in the beta-3 receptor sites in adipose (fat) tissue. Stimulation of the beta-3 receptor sites brings forth lipolysis meaning it stimulates fat metabolism. Another distinctive physiological property of Methyl Synephrine is its role as an Alpha-1 adrenergic agonist which plays a major part in the metabolization and destruction of body fat by freeing up stored body fat and allowing you to burn it for energy (lipolysis). Acting on both Alpha 1 and Beta 3 receptors to induce fat loss is why Methyl Synephrine will earn its reputation as a powerful lipolytic agent in scientific circles when is released to the general public.*
Further, adding a functional group to the chemical structure ramped up Synephrine's Beta 3 intrinsic fat burning capacity so that it worked like its chemical cousin ephedrine. So, after trying stabilization of Synephrine with HCl and failing at hydroxylation, we finally arrived at adding a Methyl functional group to Synephrine thus giving birth to Methyl Synephrine This compound was so impressive that we trade marked it as Super Synephrine™! And, of course our Super Methyl Synephrine produced effects beyond our wildest imagination with real human subjects when combined with R-ß-M-PEA and n-Methyl-ß-PEA and the other above-mentioned compounds in Meltdown.*
Tetradecylthioacetic acid (TTA) is referred to in science as having pleiotropic properties meaning that it produces many effects from a single compound. As you probably expected, these effects all relate to monster fat loss! In fact, the biological responses to TTA in regard to fat loss are so profound that it is hard to believe a fat burning agent of this diverse nature actually exists. Guess where fat is burned? It's burned in the mitochondria of the muscle cell and TTA induces mitochondrial proliferation (increases the number of mitochondria in the cell). The more mitochondria contained within a muscle cell, the greater your capacity to burn fat. So it's no wonder that another biological response to TTA is increased catabolism of fatty acids. You have probably heard the word catabolism before in reference to destroying muscle tissue which is not good; however, in the case of TTA we refer to catabolism in regard to destroying fat which is highly desired! Meltdown does NOT contain TTA. About 10 years ago I was tagged with the name "Supplement Guru" for a reason and that was because I am somewhat of a freak in the field of research and development science and also overly enthusiastic about bringing you new supplement innovations that have physique-altering properties. Therefore, although very powerful, I wasn't going to use just TTA. Instead, the goal was to turn the heat up a several hundred percent in Meltdown with M-TTA or Methyl TTA. M-TTA also promotes anti-adiposity meaning it prevents you from storing fat along with improving insulin sensitivity. If you read my Zero Impact Diet book or read the newest N.O. Shotgun article, you would know the importance of insulin sensitivity in building muscle and annihilating body fat. Other biological aspects of M-TTA are, reduced proliferation and apoptosis (death) to fat cells.*
Meltdown is the world's most scientifically sophisticated advanced fat burner. Meltdown is powered by a pharmaceutically inspired polymer based lipid delivery system called PolyLipid. This "steady state" technology delivers both rapid and sustained controlled-release of the powerful active Meltdown compounds. VPX is the father of liquid delivered fat burners in the nutritional industry and to date has engineered and sold more liquid delivered fat burning ingredients than all other companies combined! You won't catch VPX doing any mindless "capsule within a capsule" hocus pocus nonsense. PolyLipid Delivery is advanced and authentic pharmaceutical science that dramatically improves the pharmacokinetics of fat burning compounds.*
You will only find the pure R-ß-M-PEA and n-Methyl-ß-PEA powerhouse versions of PEA in Meltdown. Well, guess what? There are many other really cool fat loss ingredients in Meltdown like the bio-molecularly engineered, CCK-8, and pure cAMP. However, unfortunately, I'm out of time and this magazine was supposed to go to print today and here I'm spilling my heart and soul out to you about the greatest fat loss invention of the 21st Century.*
The effectiveness of Meltdown has been the subject of several university studies. Below are links to full study write-ups on Meltdown.
I give it a 7, only because I haven't been taking it long enough to see results. I certainly felt the difference when taking meltdown. It makes you sweat, and you feel energetic. But it is a gradual energy, evenly spread out throughout your day. Now, I will come back in about another month and let you know how the visual results have been.
I started using this product at 295 pounds. It help me down to 270. The only reason I gained weight is when I stopped working out and stopped using the product. Yes, it will make you sweat. I don't know about anyone else but it did make me hungry. Fighting the food cravings was extra difficult for me. However, if your heart is in good shape, I would recommend this. It seems it's difficult to find in stores now.
My goal was to lose 6-7lbs per month for a total loss of 40lbs. I have been taking meltdown for 6 weeks and the results have been very good. The energy is long lasting and not too full on, and it really helps me out with food cravings (esp at night). I am on target for my goals and feel much better generally. I'll definitely be buying meltdown again, and give a positive recommendation for others. Thanks.
I enjoyed Meltdown because it hasn't as full on with stimulants as other fat burners out there. The energy was smooth and lasted a long time. The big difference for me was the appetite suppressant effects it had. I found I found easily eat about 500-600 calories per day less than usual, which I think is why this product worked well for me.
Ill start off by saying that the price on M&S is a great deal! I made the mistake of buying this from the store so it was double the price. I wasnt too happy about the results, I lost mostly water weight through sweat, I used a body weight content meter to make sure. There is definitely better products out there. Ive used ECA before and green tea pills. The ECA was too powerful but it worked well. Green tea pills are my favorite, I would try green tea pills first before buying Meltdown. Theyre cheaper and natural.
This is one of the best of not the best fat burner out there at the oment. I take it every morning as basically my cup of coffee. Since it gives me a good amount of energy but not too much where Im feeling jacked out of my mind or bouncing off the walls, or worse, jittery. It kicks starts my metabolism as well and when i train i can really feel it kick in with my thermogenis being fired up. Overall great product oh and by the way have lost 18 pounds on it already in 6 weeks and held some good muscle
This product helped me with energy when running on the treadmill and working out with weights. It also helps control food cravings throughout the day. I took it first thing in the morning before breakfast, and once again in the afternoon if I needed it. It's not as potent as some other high energy pills, but I liked that. Overall, I'm giving it a 9. It lost one point because after about 3 weeks I found my body was getting used to it
I have been using this product for about 8 months and I know it works for me. About a month after taking it, while making sure to keep my eating/training habits the same and I lost about on average an additional half-pound a week. And that was while taking just 1 capsule a day. During that time (and since) I have supplemented a healthy low-fat diet with my post-workout shake and my mass and definition have increased. I'm now gaining net weight, but it is muscle mass as I've pretty much lost about as much fat as I reasonably can (without going into "competition mode") but I'm not a pro competitor. I also take about 2 a day in the morning now so I can increase my caloric intake to help put on mass. I like it because there's no cycle on/off with this product as there are with some other burners. The product gives me a good energetic feeling about 15-20 minutes afterwards and I'm ready for my day. It says you can take up to 3/day but I haven't done that yet because at 2 I'm already getting a bit jittery so I'm fine with that. Plus, in my opinion, if you eat right and exercise there's no sense in trying to over do it with these pills.
|Amount Per Serving||Amt||%DV|
|Calories from Fat||9|
|Fat Catabolizor™ & ß-3 Potentiator||317mg|
|Toothed Clubmoss (Huperzia serrata) (leaves) (std. to 1% huperizine A)||†|
|Yerba Mate (Ilex paraguariensis) Powder Extract (leaves)||†|
|3'-5'-cAMP (3'-5'-Cyclic Adenosine Monophosphate)||†|
|Super Synephrine™ ß-3 Activator™||20mg|
|Iphoric® Potent Methyl ß-3 PEA Matrix||138mg|
|NorEpiphex™ a2-Andregenic Blockade Complex||9mg|
|Yohimbe (Coryanthe yohimbe) (bark) [std. to yohimbine HCl]||†|
|Yohimbe (Coryanthe yohimbe) (bark) [std. to 11-hydroxy yohimbine]||†|
|Yohimbe (Coryanthe yohimbe) (bark) [std. to alpha-yohimbine HCl]||†|
|Barley (Hordenine vulgare) (bud) [std. to hordenine HCl]||†|
* % Daily Value is based on a 2,000 calorie diet. Your daily values may be higher or lower based on your calorie needs.
† Daily Value (DV) not established.
As a dietary supplement, the maximum recommended serving is three Meltdown® capsules. However, begin use with one to two capsules daily to assess tolerance. Never exceed more than three total capsules daily or in a single dose. As a dietary supplement take Meltdown® upon awakening.
Not for use by individuals under the age of 18 or those with a medical condition. Do not use if pregnant or nursing. Consult a physician or licensed qualified health care professional before using this product if you have, or have had a family history of heart disease, thyroid disease, diabetes, high blood pressure, depression or other psychiatric condition, glaucoma, difficulty in urinating, prostate enlargement, or seizure disorder, or if you are using a monoamine oxidase inhibitor (MAOI) or any other dietary supplement, prescription drug, or over-the-counter drug containing ephedrine, pseudoephedrine, or phenylpropanolamine (ingredients found in certain allergy, asthma, cough or cold, and weight-control products). Do not exceed recommended serving. Exceeding recommended serving may cause adverse health effects. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, severe headache, shortness of breath, or other similar symptoms. Individuals who are sensitive to the effects of caffeine or have a medical condition should consult a licensed health care professional before consuming this product. Do not use this product if you are more than 15 pounds over weight. The consumer assumes total liability if this product is used in a manner inconsistent with label guidelines. Do not use for weight reduction. Do not consume synephrine or caffeine from other sources, including but not limited to coffee, tea, soda and other dietary supplement or medications containing phenylephrine or caffeine. Contains caffeine. Do not use for more than 8 weeks. Discontinue use two weeks prior to surgery. Keep out of reach of children. Too much caffeine may cause nervousness, irritability, sleeplessness, and occasionally rapid heartbeat. Not recommended for use by children under 18 years of age. One serving of meltdown provides 275 mg of caffeine which is less than three cups of coffee.