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Core TEST is an all natural testosterone boosting supplement carefully designed to optimize endogenous hormone levels and increase your athletic performance. Core TEST supports:

• Increased testosterone levels
• Reduced estrogen
• Reduced cortisol
• Increased fat loss
• Increased sense of well-being
• Muscle mass and strength

Testosterone is the ultimate muscle building hormone. You can work out until you drop, but your muscles won’t grow without sufficient levels of this anabolic hormone. So the more circulating “Test” you have, the greater the anabolic environment for increasing muscular size and strength. Taking steroids can powerfully boost testosterone levels, but some athletes choose not to go that route, and some people want to avoid the potentially harmful side effects of exogenous hormone use. But what if you could activate the endogenous mechanisms in your body that increase testosterone production naturally?

That is where Core TEST comes in. Core TEST is an all-natural, innovative product and its ingredient are backed by numerous clinical studies demonstrating significant increases in testosterone levels. Core TEST combines potent testosterone boosting agents with a powerful, all-natural DSHEA compliant anti-aromatase, which also supports elevated testosterone levels while reducing estrogen and cortisol. In addition, as with all Core Nutritionals’ products, Core TEST’s ingredients are properly dosed and included in a non-proprietary blend formulation so you know exactly what you are supplementing.

Each 6 capsule serving of Core TEST contains:

• 4g of sodium D-aspartic acid
• 75mg of 3-desoxy, 7-keto DHEA
• 300mg of Coleus forskohlii root extract (20% forskolin)
• 1500IU of vitamin D3 (cholecalciferol)

Physiological Properties and Effects:

(Sodium) D-aspartic acid (DAA) is an amino acid that is found naturally in several endocrine glands, including the testes and pituitary. While the correlation between DAA and testosterone production has been clinically documented, research indicates several possible mechanisms for these effects. It’s likely that DAA acts as a neuromodulator influencing several pathways that govern the reproductive system, particularly testosterone production. Some studies indicate that DAA’s concentrated presence in the hypothalamus, pituitary, and testes identify this protein an up-regulator of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), growth hormone (GH), and testosterone. Some studies have found that DAA also stimulates a protein called StAR. StAR is necessary for the cholesterol transport in the cell that is needed for testosterone production (see below for another powerful ingredient of Core TEST that stimulates StAR). Further, its role in modulating the sexual drive implicates DAA as a nootropic agent, increasing levels of dopamine and seratonin that lead to improved mood and enhanced libido.

Because of these powerful anabolic effects, sodium DAA is one of the most clinically proven substances that is commercially available for supporting increased testosterone. To cite one landmark study, in August 2009 a large human study in Italy involving 43 adult men tested the effects of sodium D-aspartic acid on testosterone and luteinizing hormone production. This strict clinical trial found that “with the consumption of a daily dose of 10 ml of 2 M sodium D-aspartate solution (3.12 g) for 12 consecutive days, the levels of LH and testosterone in the serum were significantly increased, by 33% and 42% respectively.“

To replicate and improve upon these astounding results, Core TEST provides a slightly higher dose (4 g) than what was used in the study. Moreover, Core TEST uses the precise compound—sodium D-aspartic acid, rather than the cheaper D-aspartic acid—that the clinical trial found to be so effective.

By itself, however, sodium DAA acid may be problematic because it has also been shown to causes a potential increase in aromatase, which is the enzyme that converts testosterone to estrogen. To avoid this potential for elevated estrogen levels (not conducive to muscle growth), Core TEST includes another powerful ingredient:

3-desoxy, 7-keto DHEA is a unique new supplement. 7-keto DHEA is well-known in the supplement market as a fat loss and anti-cortisol product. Core TEST’s compound, 3- desoxy, 7-keto DHEA (“3D7K”), is a lesser known metabolite of DHEA that is already present in small amounts in the body naturally, and also acts as an anti-cortisol compound. But more importantly, 3D7K is a powerful anti-estrogen.

The enzyme known as aromatase is responsible for converting testosterone to estrogen in the human body. Furthermore, elevated estrogen can ultimately lead to lower testosterone levels in men (through signaling the hypothalamic pituitary testicular axis (HPTA) to shut down production of GnRH and LH). By binding to aromatase in an irreversible manner (suicide inhibitor), 3D7K effectively supports reduced estrogen levels and thus elevated testosterone levels.

Because the 3D7K in Core TEST blunts the rise of both estrogen and cortisol, it allows the increased levels of testosterone from the sodium D-aspartic acid to promote significant muscular development without the negative side effects. Like sodium D-aspartic acid, this would be a potent supplement all by itself, but in combination with the other ingredients it helps make Core TEST perhaps the most effective natural testosterone booster on the market.

Note: 3-desoxy, 7-keto DHEA (8R,9S,10R,13S,14S)- 10,13-dimethyl-2,8,9,11,12,14,15, 16-octahydro-1H-cyclopenta[a]phenanthrene-7,17-dione) is a completely natural aromatase inhibitor that complies with DSHEA regulations and does not convert to testosterone or any other banned substances (unlike other anti-estrogens recently pulled from the market).

Coleus forskohlii root extract (20% forskolin) is another powerful ingredient that helps promote fat loss and optimal testosterone levels. Forskolin generates elevated levels of 3,5 cyclic adenosine monophosphate (cAMP)—a key endocrine regulator.

Testosterone production in the leydig cells is mediated by luteinizing hormone and requires cholesterol. High cAMP levels up-regulate levels of luteinizing hormone, and also facilitate the effective transfer of cholesterol by stimulating a protein called StAR (steroidogenic acute regulator). StAR allows for faster and more efficient creation of testosterone by improving cholesterol transport and enhancing the anabolic mediation of luteinizing hormone.

Increased cAMP levels also affects adipose tissue where it promotes the burning of fat cells through lipolysis, providing increased energy. And because forskolin increases cAMP without needing epinephrine (adrenalin), this fat-burning energy production does not require artificial stimulants.

Vitamin D3 (cholecalciferol) is an essential hormone precursor that plays a vital role in many metabolic functions, including bone health, blood glucose and insulin control, immune system support, blood pressure regulation, muscle protein synthesis, and suppression of adipose tissue (body fat). Clinical trials have even linked Vitamin D3 with decreased risk of cancer. Although some foods contain vitamin D, the human body generates most of its vitamin D needs from the skin through regular exposure to sunlight. Severe vitamin D deficiency is a significant and widespread problem, especially in North America. In addition to its well-known properties for strengthening bones and controlling inflammation, Cholecalciferol is included in Core TEST because studies have shown that higher levels of vitamin D in men are correlated with higher levels of circulating testosterone.

References:

1. Arakane F, King SR, Du Y, Kallen CB, Walsh LP, Watari H, Stocco DM, Strauss JF 3rd. Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity. J Biol Chem. 1997 Dec 19;272(51):32656-62.
2. Asif AR, Ljubojevic M, Sabolic I, Shnitsar V, Metten M, Anzai N, Müller GA, Burckhardt G, Hagos Y. Regulation of steroid hormone biosynthesis enzymes and organic anion transporters by forskolin and DHEA-S treatment in adrenocortical cells. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1351-9. Epub 2006 Jul 11.
3. Assisi L, Botte V, D’Aniello A, Di Fiore MM. Enhancement of aromatase activity by D-aspartic acid in the ovary of the lizard Podarcis s. sicula. Reproduction. 2001 May;121(5):803-8.
4. Badmaev, V. Majeed, M. Conte, A, Parker, J. “Diterpene Forskolin (Coleus forskohlii, Benth.): A possible new compound for reduction of body weight by increasing lean body mass” Sabinsa Corporation http://www.b5srl.com/articles/nu/2002/marapr/badmaev.htm 1/21/2004.
5. Barger-Lux MJ, Heaney RP, Dowell S, Chen TC, Holick MF. Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men. Osteoporos Int, 1998;8:222-230.
6. André C, Berthelot A, Robert JF, Thomassin M, Guillaume YC. Testimony of the correlation between DHEA and bioavailable testosterone using a biochromatographic concept: effect of two salts. J Pharm Biomed An., 2003 Dec 4: 33(5): 911-21.
7. Cannell, J. J., et. al., Athletic Performance and Vitamin D. Medicine and Science in Sports and Exercise, 2009; 41(5):1102-1110
8. Ding X, Staudinger J. Induction of Drug Metabolism by Forskolin, the Role of The Pregnane X Receptor and the PKA Signal Transduction Pathway. J Pharmacol Exp Ther. 2004 Sep 30.
9. D’Aniello A. D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role. Brain Res Rev. 2007 Feb;53(2):215-34.
10. D’Aniello A, Di Fiore MM, D’Aniello G, Colin FE, Lewis G, Setchell BP. Secretion of D-aspartic acid by the rat testis and its role in endocrinology of the testis and spermatogenesis. FEBS Lett. 1998 Sep 25;436(1):23-7.
11. D’Aniello A, Di Cosmo A, Di Cristo C, Annunziato L, Petrucelli L, Fisher G. Involvement of D-aspartic acid in the synthesis of testosterone in rat testes. Life Sci. 1996;59(2):97-104.
12. Lamanna C, Assisi L, Botte V, Di Fiore MM. Involvement of D-Asp in P450 aromatase activity and estrogen receptors in boar testis. Amino Acids. 2007 Jan;32(1):45-51. Epub 2006 Jun 1.
13. Lamanna C, Assisi L, Botte V, Di Fiore MM. Endogenous testicular D-aspartic acid regulates gonadal aromatase activity in boar. J Endocrinol Invest. 2006 Feb;29(2):141-6.
14. Michael P. Godard, Brad A. Johnson and Scott R. Richmond. Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men. Obesity Research (2005) 13, 1335–1343; doi: 10.1038/oby.2005.162.
15. Keeney DS, Mason JI. Cecil H. and Ida Green. Expression of testicular 3 beta-hydroxysteroid dehydrogenase/delta 5—-4-isomerase: regulation by luteinizing hormone and forskolin in Leydig cells of adult rats. Center for Reproductive Biology Sciences, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235-9051.
16. Kreider RB, et al. Effects of Coleus forskohlii supplementation on body composition and markers of health in sedentary overweight females. Experimental Biology 2002 Late Breaking Abstracts. LB305: 2002.
17. Leamon, KB; Padgett, W; Daly, JW. “Forskolin: Unique diterpene activator of adenylate cyclase in membrane and intact cells” Proc. Natl. Acad. Sci. USA 1981,78,3363-67.
18. Mitsuteru Numazawa, Ayako Mutsumi, Mii Tachibana,and Kumiko Hoshi. Synthesis of Androst-5-en-7-ones and Androsta-3,5-dien-7-ones and Their Related 7-Deoxy Analogs as Conformational and Catalytic Probes for the Active Site of Aromatase. J. Med. Chem. 1994, 37, 2198-2205.
19. Nagata Y, Homma H, Matsumoto M, Imai K. Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells. FEBS Lett. 1999 Jul 9;454(3):317-20.
20. Pinilla L, Tena-Sempere M, Aguilar E. Role of excitatory amino acid pathways in control of gonadotrophin secretion in adult female rats sterilized by neonatal administration of oestradiol or testosterone. J Reprod Fertil. 1998 May;113(1):53-9.
21. Schubert K, Wehrberger K, Hobe G. Androsta-3,5-diene-7,17-dione: isolation from urine and formation from 7-keto-dehydro-epiandrosterone sulphate under various conditions of hydrolysis. Endocrinol Exp. 1971 Dec;5(4):205-10.
22. Topo E, Soricelli A, D’Aniello A, Ronsini S, D’Aniello G. The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. Reprod Biol Endocrinol. 2009 Oct 27;7:120.
23. Wehr, E., et al. Association of vitamin D status with serum androgen levels in men. Clinical Endocrinology, December 2009; DOI: 10.1111